Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes

Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.

OBJECTIVE Latent autoimmune diabetes in adults (LADA) is often considered a slowly progressing subtype of type 1 diabetes, although the clinical picture more resembles type 2 diabetes. One way to improve classification is to study whether LADA shares genetic features with type 1 and/or type 2 diabetes. RESEARCH DESIGN AND METHODS To accomplish this, we studied whether LADA shares variation in...

Genetic similarities between latent autoimmune diabetes and type 1 and type 2 diabetes.

In this issue of Diabetes, Cervin et al. (1) investigated whether patients with latent autoimmune diabetes in adults (LADA) (defined as age at diabetes onset 35 years, GADA positive), analyzing known risk alleles for type 1 and type 2 diabetes, share genetic polymorphisms with type 1 diabetes (age at onset 35 years) and/or type 2 diabetes (age at onset 35 years, GADA negative). In their LADA pa...

Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults.

Despite the notion that there is a degree of commonality to the biological etiology of type 1 diabetes (T1D) and type 2 diabetes (T2D), the lack of overlap in the genetic factors underpinning each of them suggests very distinct mechanisms. A disorder considered to be at the "intersection" of these two diseases is "latent autoimmune diabetes in adults" (LADA). Interestingly, genetic signals from...

Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes

BACKGROUND LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes. METHODS Patients with LADA were matched fo...

Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults